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Top 10 Ozempic Side Effects You Should Know About

September 24, 2025
ozempic side effects

Ozempic (and Wegovy and Mounjaro) are game-changers for diabetes and, more recently, weight loss, but like any medication, they come with side effects. Here’s a quick rundown of the most common Ozempic side effects, how to manage them, and how to spot them early.

  1. Nausea & Vomiting
    • This is the #1 complaint. Your stomach empties slower, so you feel fuller — but also queasier. This tends to improve after a few weeks.
  2. Diarrhea & Constipation
    • Your gut may be doing gymnastics until your body adjusts, leading to changes in bathroom habits. Staying hydrated helps.
  3. Gallbladder Issues
  4. Pancreatitis (Rare)
    • If you’re feeling severe abdominal pain that radiates to your back, that could signal pancreas inflammation. Call your doctor right away if this happens.
  5. Low Blood Sugar
    • Low blood sugar becomes a concern if you’re also on insulin or certain diabetes drugs.
  6. Kidney Stress
    • Dehydration from vomiting or diarrhea can cause strain on your kidneys.
  7. Allergic Reactions
    • Though allergic reactions are rare, you should stop using the medicine immediately at the first signs of swelling, rash, or trouble breathing and speak to your doctor.
  8. Thyroid Concerns
    • Some animal studies showed an increase of thyroid tumors after using the medication. Human risk isn’t clear, but it might be best to avoid if you have a history of thyroid cancer or MEN 2.
  9. “Ozempic Face”
    • “Ozempic Face” refers to the face looking gaunt or saggy following rapid weight loss. It’s more about fat loss than the drug itself.
  10. Rare Side Effects, But With Emerging Reports

Managing Ozempic Side Effects

A few tips to manage the side effects of Ozempic or Wegovy drugs are to stick to gradual dose increases, eat smaller meals and non-greasy foods, and stay hydrated. And, of course, work closely with a physician and keep them in the loop if your symptoms begin to feel unusual or severe.

The bottom line is that Ozempic side effects are primarily mild and temporary. But it’s worth knowing the rare risks so you can catch them early. Always check in with your healthcare provider if something feels off. If you’re ready to start your weight loss journey, schedule an appointment today.

By KindlyMD
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